Mounjaro vs Ozempic: What’s the difference between these 2 diabetes and weight loss drugs?

Weight problems is a worldwide pandemic. In accordance with the World Well being Group (WHO), grownup weight problems on this planet greater than doubled between 1990 and 2022. This has led to extra well being issues starting from cardiovascular illnesses, diabetes and neurological problems, continual respiratory illnesses and digestive points. On this state of affairs, it’s in individuals’s greatest curiosity to keep up wholesome weight. Nonetheless, the pursuit of reducing weight shortly is main individuals to search out options in medication meant for diabetes administration, however which additionally result in weight reduction. Ozempic and Mounjaro are two such weight reduction medication which have brought on a stir globally. Are they related or completely different? Allow us to break down the Ozempic vs Mounjaro debate for you!

How does Mounjaro work?

Mounjaro (tirzepatide) is a novel injectable treatment developed for the therapy of kind 2 diabetes, however can also be used as a weight reduction drug. “It’s a twin glucose- dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist,” says diabetologist Dr Shankar Kumar Venkatarayaraju. So, it mimics the actions of each GIP and GLP-1 hormones that management blood sugar ranges and scale back urge for food, resulting in weight reduction.

The drug, out there in prefilled pen, is run as soon as weekly by way of subcutaneous injection, which suggests it’s injected beneath the pores and skin of the stomach, thigh or higher arm. It’s accredited by the US Meals and Drug Administration for kind 2 diabetes, with off-label use for weight problems.

How does Ozempic work?

Ozempic (semaglutide) is a once-weekly injectable treatment meant for kind 2 diabetes administration and used off-label for weight reduction. “It’s a GLP-1 receptor agonist that mimics endogenous glucagon-like peptide-1,” shares the professional. It will increase the degrees of intestine hormones, incretins, and helps to provide extra insulin when wanted. It additionally helps in decreasing the quantity of sugar produced by the liver, and slows down digestion of meals. These mechanisms assist to decrease blood sugar ranges and contribute to weight reduction.

Mounjaro vs Ozempic: What are the similarities?

Each the medicines are related in a number of methods.

1. Not accredited for weight reduction

Mounjaro shouldn’t be accredited by the FDA for weight reduction despite the fact that tirzepatide, which is its lively ingredient, bought a inexperienced sign for weight reduction beneath the model title Zepbound. Equally, Ozempic can also be not accredited for this objective. The one accredited by the FDA for weight administration is Wegovy, which additionally makes use of semaglutide, the primary ingredient in Ozempic.

2. Weekly injectable medicines

Relating to Mounjaro vs Ozempic, each are weekly injectable medicines used to deal with kind 2 diabetes, and work as weight reduction medication. They work by way of incretin hormone pathways to decrease blood sugar ranges and suppress urge for food, resulting in weight reduction.

3. Administered subcutaneously

Each the medication are administered subcutaneously and require dose titration (gradual addition of 1 answer of a focus that’s already identified). These are necessary, as they’ll scale back gastrointestinal unwanted side effects akin to nausea, vomiting and diarrhea.

“Additionally, each the medicines, that are advisable after failure of first-line brokers like metformin, present beneficial cardiovascular and metabolic profiles, and will not be appropriate for kind 1 diabetes,” says Dr Venkatarayaraju.

Mounjaro vs Ozempic: What are the variations between them?

Listed here are some key variations between Mounjaro and Ozempic:

1. Mounjaro vs Ozempic: Substances and mechanism

Mounjaro (tirzepatide) is a twin GIP/GLP-1 receptor agonist, whereas Ozempic (semaglutide) targets solely the GLP-1 receptor. This twin concentrating on in Mounjaro gives doubtlessly optimistic results on metabolism, and helps with weight reduction.

2. Mounjaro vs Ozempic: Dose

Whereas each are administered subcutaneously as soon as in per week, the doses are completely different. “Mounjaro is out there in doses from 2.5 to fifteen mg weekly, whereas Ozempic is often titrated as much as 2 mg,” says the professional.

3. Mounjaro vs Ozempic: Security

Ozempic, which was launched in 2017 within the US, has extra intensive long-term knowledge, together with optimistic cardiovascular outcomes in individuals with kind 2 diabetes. “Mounjaro’s long-term security remains to be beneath analysis, though early knowledge is promising,” based on Dr Venkatarayaraju.

Mounjaro vs Ozempic: Which one is healthier?

From a medical efficacy standpoint, Mounjaro seems superior to Ozempic for each glycemic management and weight reduction. Throughout a research, printed in JAMA Inner Drugs, individuals who had been chubby or overweight used tirzepatide and semaglutide. They skilled considerably larger weight reduction after they used tirzepatide.

“Nonetheless, ‘higher’ additionally is determined by patient-specific components. Ozempic has a powerful cardiovascular knowledge, together with FDA approval for decreasing main cardiovascular occasions in high-risk individuals. Mounjaro doesn’t but have this label,” says the professional.

Within the Mounjaro vs Ozempic battle, the previous could also be most well-liked when maximal weight reduction and glycemic management are major objectives. Ozempic could also be chosen when cardiovascular safety is a precedence.

Mounjaro vs Ozempic: Unintended effects

Listed here are a number of the unwanted side effects:

Mounjaro unwanted side effects

• Stomach bloating
• Stomach ache
• Constipation
• Flatulence
• Diarrhea
• Nausea
• Lack of urge for food
• Discomfort or discolouration across the spot the place the medication was injected

Ozempic unwanted side effects

• Stomach ache
• Constipation
• Diarrhea
• Indigestion
• Discomfort across the injection space

Whereas these unwanted side effects of Ozempic and Mounjaro could also be momentary, there could be severe dangers too. “They’re uncommon, however individuals utilizing each might find yourself with pancreatitis, thyroid tumors and gallbladder illness,” says the professional.

Within the Mounjaro vs Ozempic debate, there isn’t a clear winner. Their lively substances are completely different, however their well being objectives, unwanted side effects, and routes of administration overlap significantly.